Data Analytic Center RFA Questions & Answers

Please see below for additional information about the AACVPR Data Analytic Center Request for Applications. Any additional questions can be directed to kmaude@aacvpr.org


1.    Do you have an estimated number of investigator initiated proposals that come through the center each year?

 

No. At this time, since we have never opened up the registry data for research, we do not know how many proposals to anticipate.  However, we expect that the PI of the Data Analytic Center will work closely with the AACVPR research committee to determine an appropriate budget and time frame for investigator initiated proposals.

2.    What is the frequency of the internal AACVPR analyses?

 

We do not expect this to be a frequent occurrence.  We expect that there will intermittently be requests to perform simple analyses to assist with committee work, performance measure endorsement, or to provide a limited number of analyses as a portion of an AACVPR commissioned manuscript, etc.  These types of questions would just require a quick look at a data variable or a small number of variables to quickly answer a question or perform a limited number of analyses.  We are requesting in this RFA that these types of analyses be performed as part of the existing scope of work.  However, if a larger project such as a full manuscript or major scientific statement were to be written, we would consider that type of project to be outside of this scope of work and would provide additional funding for that type of analysis.

 

3.    How many internal AACVPR analyses do you currently have in place?

 

At this time, there are no internal analyses planned.  See the answer to question #2 for more information on internal analyses.

 

4.    Do you currently have a vendor providing internal analyses?

No. See above responses for more details.

5.    Would the expectation be that the Data Analytic Center continue to use existing data management methodology or would the Center be allowed to house the data in another type of data management environment (e.g. REDCap, RAVE, others, etc.).

 

We plan to provide the Data Analytic Center with a limited data set, as defined by HIPAA, of the existing AACVPR registry data with which to work from.  This limited data set could be stored in any appropriate data management environment by the Data Analytic Center that would ensure the security of the data and comply with local IRB regulations. Please note that the Data Analytic Center will not be responsible for collecting any new data, which is the most common use for applications such as REDCap or RAVE.  The Data Analytic Center will only perform analyses on the existing data.

 

6.    Are you planning to have a single vendor for the data analytic center or more than one?  If more than one, how many?

 
We will only be selecting one institution.

7.    Is there a minimum or maximum number of years of funding for the Data Analytic Center proposed in this announcement?

 
The initial contract will be for one year with plans to renew on an annual basis.  It is expected that the data management function covered by this scope of work will become less time intensive over time. This should allow for more time to be dedicated to the performance of investigator initiated analyses, which will be funded by separate mechanisms.  As a result, it is likely that the level of support from AACVPR will decrease, while support from investigator initiated analyses will increase.  However, the exact timing of this will depend on data management needs and will be jointly discussed between AACVPR and the members of the Data Analytic Center on an annual basis.

8.    Will AACVPR provide a de-identified standardized limited dataset or a data dump of all registry data to the Data Analytic Center?

We are willing to discuss other options once the Data Analytic Center is established, but at present, we plan to provide a limited data set as defined by HIPAA, due to the lack of informed consent for research.  We anticipate that this will be necessary to comply with local IRB and HIPAA regulations.  We also expect to need to have a data use agreement, business associates agreement, or similar agreement established between AACVPR and the Data Analytic Center.

9.   Will Cissec act as an honest broker to merge registry data with limited external data (e.g. census data) for research purposes?

 

      The merging of AACVPR registry data with external data sources is outside the scope of work of this RFA.  At present, we view the RFA as a mechanism to establish an infrastructure with which to use the existing AACVPR registry data for research.  To accomplish this, we will provide the Data Analytic Center with a limited data set.  Clearly, however, there will be opportunities to merge these data with other external data sources.  That will require additional external funding beyond the funds provided in this RFA.  Once the Data Analytic Center is established and the initial infrastructure is built around our existing registry data, AACVPR can help coordinate conversations between our registry vendors and the Data Analytic Center to work on mechanisms to perform these types of linkages.


10.  Thank you for the list of the data elements for each registry. Will the analytic center also have access to data on the individual programs/facilities contributing to each registry?

The current scope of work will not provide for linking of program level data beyond what is already collected in the registry.

11.  Will Cissec provide free data hosting for analytic data? For example, if Cissec will not act as an honest broker, can a member of my organization perform these computations within the Cissec computing environment before providing a de-identified limited dataset to the analytic team?

In the current scope of work, a limited data set will be provided to the Data Analytic Center.  That limited data set will be stored locally at the Data Analytic Center as described in the answer to question #5.

12.  Will the PI of the Analytic Center have the ability to propose research projects with the registry data? If yes, please confirm that PI proposals will have all Analytic Center fees waived.

 

Yes, the PI of the Data Analytic Center will be able to propose research projects to the research committee through the usual process.  If approved by the research committee, the fees that would be paid to the Data Analytic Center for the performance of these analyses could be waived as they are meant to reimburse the staff of the Data Analytic Center for the analyses, as long as these analyses do not come at the expense of the usual data management function established by the scope of work defined in this RFA or other approved analyses.